SER1/YOR184W Summary Help

Standard Name SER1 1, 2
Systematic Name YOR184W
Alias ADE9 3
Feature Type ORF, Verified
Description 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress (3, 4, 5, 6)
Name Description SERine requiring 7
Chromosomal Location
ChrXV:679357 to 680544 | ORF Map | GBrowse
Gbrowse
Genetic position: 98.2 cM
Gene Ontology Annotations All SER1 GO evidence and references
  View Computational GO annotations for SER1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 6 genes
Resources
Pathways
Classical genetics
null
reduction of function
Large-scale survey
null
Resources
121 total interaction(s) for 101 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 12
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 1
  • PCA: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 80
  • Positive Genetic: 7
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 7
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 395
Molecular Weight (Da) 43,415
Isoelectric Point (pI) 6.52
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:679357 to 680544 | ORF Map | GBrowse
SGD ORF map
Genetic position: 98.2 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1188 679357..680544 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005710
References cited on this page View Complete Literature Guide for SER1
1) Johnston, J.R.  (1962) Studies in meiotic and mitotic recombination in Saccharomyces cerevisiae. Ph.D Thesis
2) Lowenstein, R.  (1973) Genetic studies in Saccharomyces cerevisiae. Ph.D Thesis
3) Buc PS and Rolfes RJ  (1999) ade9 is an allele of SER1 and plays an indirect role in purine biosynthesis. Yeast 15(13):1347-55
4) Melcher K and Entian KD  (1992) Genetic analysis of serine biosynthesis and glucose repression in yeast. Curr Genet 21(4-5):295-300
5) Melcher K, et al.  (1995) Molecular analysis of the yeast SER1 gene encoding 3-phosphoserine aminotransferase: regulation by general control and serine repression. Curr Genet 27(6):501-8
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
7) Ogur M, et al.  (1977) "Active" one-carbon generation in Saccharomyces cerevisiae. J Bacteriol 129(2):926-33