Complex: 6-phosphofructokinase complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-554
- Systematic Name
- 4xPFK1:4xPFK2
- SGD ID
- SGD:S000218025
- Aliases
- 6-phosphofructokinase ; 6PF-1-K complex ; PFK complex ; Pfk-1 complex ; phosphofructokinase ; phosphohexokinase
- Description
- Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate in the presence of MgATP, the first irreversible step for glycolysis. The enzyme is stablilized in the presence of Fructose 6-P and exhibits cooperative binding of Fructose 6-P. Its activity is controlled by many allosteric activators and inhibitors (including ATP), showing its crucial role in regulation of glycolytic flux. The enzyme can exist in either the active R-state or inhibited T-state. The effectors either modulate the affinity of Pfk for Fructose 6-P or overcome inhibitory effects. Pfk is an octamer composed of 4 alpha and 4 beta subunits.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
PDB Structure
When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.
| 3O8O |
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables 6-phosphofructokinase activity (IDA)
- enables fructose-6-phosphate binding (IPI)
- Biological Process
-
- involved in fructose 6-phosphate metabolic process (IDA)
- involved in glycolytic process (IDA)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
No shared annotations
References
List of references used specifically to curate the information on this page.
- Reuter R, et al. (2000) Purification, molecular and kinetic characterization of phosphofructokinase-1 from the yeast Schizosaccharomyces pombe: evidence for an unusual subunit composition. Yeast 16(14):1273-85 PMID: 11015725
Resources
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