Complex: Elongator holoenzyme complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-779
- Systematic Name
- IKI3:ELP2:ELP3:ELP4:IKI1:ELP6
- SGD ID
- SGD:S000217904
- Aliases
- RNA polymerase II elongator complex ; elongator complex
- Description
- N-acetyltransferase which acts to form modified wobble uridines in tRNA, such as 5-methoxycarbonylmethyl-uridine (mcm5U), 5-methoxycarbonylmethyl-2-thio-uridine (mcm5s2U), and 5-carbamoylmethyl-uridine (ncm5U). These sites influence the recognition rate and affinity between incoming tRNAs and codons in the A site of the translating ribosome, stablizing transient pausing events thus supporting proper domain folding of the nascent polypeptide chains during the elongation phase of the ribosome‐mediated translation process.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables N-acetyltransferase activity (BSR)
- enables tRNA binding (BSR)
- Biological Process
-
- involved in regulation of translation (BSR)
- involved in tRNA wobble uridine modification (BSR)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Jaciuk M, et al. (2023) Cryo-EM structure of the fully assembled Elongator complex. Nucleic Acids Res 51(5):2011-2032 PMID: 36617428
- Dauden MI, et al. (2019) Molecular basis of tRNA recognition by the Elongator complex. Sci Adv 5(7):eaaw2326 PMID: 31309145
- Dauden MI, et al. (2017) Architecture of the yeast Elongator complex. EMBO Rep 18(2):264-279 PMID: 27974378
- Johansson MJ, et al. (2008) Eukaryotic wobble uridine modifications promote a functionally redundant decoding system. Mol Cell Biol 28(10):3301-12 PMID: 18332122
- Li B, et al. (2007) The role of chromatin during transcription. Cell 128(4):707-19 PMID: 17320508
Resources
IntAct | ModelArchive | PDB:4A8J | PDB:6QK7 | PDB:8ASV ... Show all Show fewer