Protein abundance data, domains, shared domains with other proteins, protein sequence retrieval for various strains, sequence-based physico-chemical properties, protein modification sites, and external identifiers for the protein.
AlphaFold, developed by DeepMind, is an AI program that accurately predicts protein structures from amino acid sequences, enabling visualization of protein conformations. The predicted structures can be accessed through the Protein Data Bank (PDB) and AlphaFold Protein Structure Database.
Contains experimentally-derived protein half-life data obtained using stable isotope labeling by amino acids (SILAC) coupled with mass spectrometry. This section also contains protein abundance data for both untreated and treated cells obtained from over 20 studies. These data have been normalized and converted to a common unit of molecules per cell.
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Abundance (molecules/cell) | Media | Treatment | Treatment time | Fold Change | Visualization | Strain background | Original Reference | Reference |
---|---|---|---|---|---|---|---|---|
1809 | SD | untreated | confocal microscopy evidence | S288C | Breker M, et al. (2013) | Ho B, et al. (2018) | ||
1510 | SD | 2 mM 1,4-dithiothreitol | 2 hr | confocal microscopy evidence | S288C | Breker M, et al. (2013) | Ho B, et al. (2018) | |
1761 | SD | 1 mM hydrogen peroxide | 1 hr | confocal microscopy evidence | S288C | Breker M, et al. (2013) | Ho B, et al. (2018) | |
1460 | SD minus nitrogen | cellular response to nitrogen starvation | 15 hr | confocal microscopy evidence | S288C | Breker M, et al. (2013) | Ho B, et al. (2018) | |
1708 | SD | untreated | confocal microscopy evidence | S288C | Chong YT, et al. (2015) | Ho B, et al. (2018) |
Collection of computationally identified domains and motifs, as determined by InterProScan analysis; includes protein coordinates for the domain, a domain Description, a Source and corresponding accession ID, and the number of S. cerevisiae genes that share the same domain.
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Evidence ID | Analyze ID | Gene | Gene Systematic Name | Protein Coordinates | Accession ID | Description | Source | No. of Genes with Domain |
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Visual representation of the locations of the domains within the protein, as listed in the Domains and Classification table. Each row displays the domain(s) derived from a different Source, with domains color-coded according to this Source.
Scroll over a domain to view its exact coordinates and its Description.
Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results.
View all BRR2 alleles in SGD search
Protein sequence for the given gene in S288C and other strains, when available. Use the pull-down menu under "Strain" to select the sequence for a specific strain. The displayed sequence can be downloaded in FASTA format as a .txt file. Amino acids displayed in blue represent modification sites. More detailed evidence for these modification sites is presented in the Post-translational Modifications table, located just below the protein sequence.
This locus is not translated into a protein.
1 MTEHETKDKA KKIREIYRYD EMSNKVLKVD KRFMNTSQNP QRDAEISQPK SMSGRISAKD
61 MGQGLCNNIN KGLKENDVAV EKTGKSASLK KIQQHNTILN SSSDFRLHYY PKDPSNVETY
121 EQILQWVTEV LGNDIPHDLI IGTADIFIRQ LKENEENEDG NIEERKEKIQ HELGINIDSL
181 KFNELVKLMK NITDYETHPD NSNKQAVAIL ADDEKSDEEE VTEMSNNANV LGGEINDNED
241 DDEEYDYNDV EVNSKKKNKR ALPNIENDII KLSDSKTSNI ESVPIYSIDE FFLQRKLRSE
301 LGYKDTSVIQ DLSEKILNDI ETLEHNPVAL EQKLVDLLKF ENISLAEFIL KNRSTIFWGI
361 RLAKSTENEI PNLIEKMVAK GLNDLVEQYK FRETTHSKRE LDSGDDQPQS SEAKRTKFSN
421 PAIPPVIDLE KIKFDESSKL MTVTKVSLPE GSFKRVKPQY DEIHIPAPSK PVIDYELKEI
481 TSLPDWCQEA FPSSETTSLN PIQSKVFHAA FEGDSNMLIC APTGSGKTNI ALLTVLKALS
541 HHYNPKTKKL NLSAFKIVYI APLKALVQEQ VREFQRRLAF LGIKVAELTG DSRLSRKQID
601 ETQVLVSTPE KWDITTRNSN NLAIVELVRL LIIDEIHLLH DDRGPVLESI VARTFWASKY
661 GQEYPRIIGL SATLPNYEDV GRFLRVPKEG LFYFDSSFRP CPLSQQFCGI KERNSLKKLK
721 AMNDACYEKV LESINEGNQI IVFVHSRKET SRTATWLKNK FAEENITHKL TKNDAGSKQI
781 LKTEAANVLD PSLRKLIESG IGTHHAGLTR SDRSLSEDLF ADGLLQVLVC TATLAWGVNL
841 PAHTVIIKGT DVYSPEKGSW EQLSPQDVLQ MLGRAGRPRY DTFGEGIIIT DQSNVQYYLS
901 VLNQQLPIES QFVSKLVDNL NAEVVAGNIK CRNDAVNWLA YTYLYVRMLA SPMLYKVPDI
961 SSDGQLKKFR ESLVHSALCI LKEQELVLYD AENDVIEATD LGNIASSFYI NHASMDVYNR
1021 ELDEHTTQID LFRIFSMSEE FKYVSVRYEE KRELKQLLEK APIPIREDID DPLAKVNVLL
1081 QSYFSQLKFE GFALNSDIVF IHQNAGRLLR AMFEICLKRG WGHPTRMLLN LCKSATTKMW
1141 PTNCPLRQFK TCPVEVIKRL EASTVPWGDY LQLETPAEVG RAIRSEKYGK QVYDLLKRFP
1201 KMSVTCNAQP ITRSVMRFNI EIIADWIWDM NVHGSLEPFL LMLEDTDGDS ILYYDVLFIT
1261 PDIVGHEFTL SFTYELKQHN QNNLPPNFFL TLISENWWHS EFEIPVSFNG FKLPKKFPPP
1321 TPLLENISIS TSELGNDDFS EVFEFKTFNK IQSQVFESLY NSNDSVFVGS GKGTGKTAMA
1381 ELALLNHWRQ NKGRAVYINP SGEKIDFLLS DWNKRFSHLA GGKIINKLGN DPSLNLKLLA
1441 KSHVLLATPV QFELLSRRWR QRKNIQSLEL MIYDDAHEIS QGVYGAVYET LISRMIFIAT
1501 QLEKKIRFVC LSNCLANARD FGEWAGMTKS NIYNFSPSER IEPLEINIQS FKDVEHISFN
1561 FSMLQMAFEA SAAAAGNRNS SSVFLPSRKD CMEVASAFMK FSKAIEWDML NVEEEQIVPY
1621 IEKLTDGHLR APLKHGVGIL YKGMASNDER IVKRLYEYGA VSVLLISKDC SAFACKTDEV
1681 IILGTNLYDG AEHKYMPYTI NELLEMVGLA SGNDSMAGKV LILTSHNMKA YYKKFLIEPL
1741 PTESYLQYII HDTLNNEIAN SIIQSKQDCV DWFTYSYFYR RIHVNPSYYG VRDTSPHGIS
1801 VFLSNLVETC LNDLVESSFI EIDDTEAEVT AEVNGGDDEA TEIISTLSNG LIASHYGVSF
1861 FTIQSFVSSL SNTSTLKNML YVLSTAVEFE SVPLRKGDRA LLVKLSKRLP LRFPEHTSSG
1921 SVSFKVFLLL QAYFSRLELP VDFQNDLKDI LEKVVPLINV VVDILSANGY LNATTAMDLA
1981 QMLIQGVWDV DNPLRQIPHF NNKILEKCKE INVETVYDIM ALEDEERDEI LTLTDSQLAQ
2041 VAAFVNNYPN VELTYSLNNS DSLISGVKQK ITIQLTRDVE PENLQVTSEK YPFDKLESWW
2101 LVLGEVSKKE LYAIKKVTLN KETQQYELEF DTPTSGKHNL TIWCVCDSYL DADKELSFEI
2161 NVK*
* Blue amino acids indicate modification sites. More information below.
Modification sites for the protein in the selected strain, based on the presence of a residue in the specific strain, as inferred from experimental evidence.
23 entries for 17 sitesIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
Site | Modification | Modifier | Reference |
---|---|---|---|
K12 | sumoylated lysine | Bhagwat NR, et al. (2021) PMID: 33502312 | |
Y19 | phosphorylated residue | Bhagwat NR, et al. (2021) PMID: 33502312 | |
K25 | sumoylated lysine | Bhagwat NR, et al. (2021) PMID: 33502312 | |
S37 | phosphorylated residue | Lanz MC, et al. (2021) PMID: 33491328 | |
S101 | phosphorylated residue | Lanz MC, et al. (2021) PMID: 33491328 | |
S216 | phosphorylated residue | Lanz MC, et al. (2021) PMID: 33491328 | |
K304 | monoacetylated residue | Henriksen P, et al. (2012) PMID: 22865919 | |
S403 | phosphorylated residue | Zhou X, et al. (2021) PMID: 33481703 | |
S403 | phosphorylated residue | Soulard A, et al. (2010) PMID: 20702584 | |
S403 | phosphorylated residue | Albuquerque CP, et al. (2008) PMID: 18407956 |
Calculated protein properties, including amino acid composition, length, coding region calculations, and atomic composition.
Sort table using the arrow to the right of a column header to sort by that column; download all properties as a .txt file using the "Download Properties" button.
Amino Acid | Frequency | Percentage |
---|---|---|
A | 116 | 5.36 |
C | 24 | 1.11 |
D | 128 | 5.92 |
E | 176 | 8.14 |
F | 93 | 4.30 |
G | 92 | 4.25 |
H | 44 | 2.03 |
I | 155 | 7.17 |
K | 157 | 7.26 |
L | 232 | 10.73 |
M | 41 | 1.90 |
N | 135 | 6.24 |
P | 85 | 3.93 |
Q | 79 | 3.65 |
R | 85 | 3.93 |
S | 177 | 8.18 |
T | 109 | 5.04 |
V | 136 | 6.29 |
W | 26 | 1.20 |
Y | 73 | 3.37 |
Length (a.a): | 2163 |
Molecular Weight (Da): | 246125.2 |
Isoelectric Point (pl): | 5.18 |
Formula: | C11026H17289N2903O3345S65 |
Aliphatic Index: | 88.63 |
Instability Index: | 43.57 |
Codon Bias: | 0.01 |
Codon Adaptation Index: | 0.13 |
Frequence of Optimal Codons: | 0.44 |
Hydropathicity of Protein: | -0.32 |
Aromaticity Score: | 0.09 |
ALL Cys residues appear as half cystines: | 253270.0 |
NO Cys residues appear as half cystines: | 251770.0 |
Sort table using the arrow to the right of a column header to sort by that column; download all properties as a .txt file using the "Download Properties" button.
Atom | Frequency | Percentage |
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Data not found or not available for S288C
List of external identifiers for the protein from various database sources.
34 entries for 11 sourcesIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
AGD | AnalogYeast | BLASTP at NCBI | CGD | FungiDB | PhylomeDB | PomBase | YGOB | YOGY
AlphaFold Protein Structure | GPMDB | ModelArchive | Pfam domains | SUPERFAMILY | TopologYeast | UniProtKB
CYCLoPs | dHITS | LoQAtE | YeastGFP | YeastRC Public Images | YeastRGB | YPL+