VPS36 / YLR417W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

VPS36/YLR417W is a non-essential gene; null mutants are viable but exhibit a range of phenotypic changes including decreased acquired thermotolerance, decreased autophagy and mitophagy, decreased biofilm formation, abnormal chemical compound accumulation and excretion, decreased endocytosis, altered metal resistance, decreased protein secretion, decreased protein/peptide accumulation, abnormal protein/peptide distribution and modification, decreased resistance to chemicals, abnormal and absent vacuolar transport, decreased acid pH resistance, auxotrophy, abnormal colony appearance, altered competitive fitness, decreased desiccation resistance, increased heat sensitivity, decreased hyperosmotic stress resistance, increased nutrient utilization, decreased oxidative stress resistance, decreased replicative lifespan, decreased respiratory growth rate, decreased sporulation efficiency, decreased telomere length, decreased toxin resistance, decreased transposable element transposition, decreased utilization rates of carbon sources, abnormal vacuolar morphology, and decreased vegetative growth rate. Overexpression of VPS36 results in decreased vegetative growth, while reduction of function mutants exhibit abnormal vacuolar transport.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources