SUS1 / YBR111W-A Overview

Standard Name
SUS1 1
Systematic Name
Feature Type
ORF , Verified
Global transcriptional regulator, component of SAGA, TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to nuclear periphery and to non-nascent mRNP; plays role in negatively regulating telomere length through modulation of H2BK123 mono-ubiquitination and its interaction with nuclear pore complex 1 2 3 4 5 6 7 8 9 10
Name Description
Sl gene Upstream of ySa1 1
Comparative Info
Sequence Details


The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C. Download DNA or protein sequence, view genomic context and coordinates. Click "Sequence Details" to view all sequence information for this locus, including that for other strains.

SUS1 is located on the right arm of chromosome II between YSA1 ADP-ribose pyrophosphatase and CYC8 general transcriptional co-repressor; coding sequence is 441 nucleotides long with two introns at 72..151 and 292..361, two intronic SNPs, one variable T mononucleotide repeat within the 2nd intron, one synonymous SNP, and one SNP that causes a Glu/Lys polymorphism at residue 90
Protein Details


Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein.

Sus1p is 96 amino acids long, low in abundance; phosphorylated on T95, ubiquitinylated on K30
Length (a.a.)
Mol. Weight (Da)
Isoelectric Point
Median Abundance (molecules/cell)
2657 +/- 719


Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results.

View all SUS1 alleles in SGD search

Gene Ontology Details

Gene Ontology

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.

Transcription coactivator subunit of the SAGA, DUBm and TREX-2 complexes; involved in many processes including regulation of transcription, mRNA export, histone deubiquitnation and histone methylation; localized to the nuclear pore and nucleoplasm

View computational annotations

Molecular Function

Manually Curated

Cellular Component

Manually Curated


Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.

Phenotype Details


Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.

Non-essential gene; null mutant is sensitive to rapamycin, hydroxyurea, methyl methanesulfonate, heat; null mutant shows increased levels of Lys123 ubiquitinated H2B, decreased poly(A)+ RNA export, increased mitotic recombination, significantly altered free amino acid profile
Interaction Details


Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.

Sus1p interacts physically with proteins involved in transcription; SUS1 interacts genetically with genes involved in transcription

757 total interactions for 425 unique genes

Physical Interactions

  • Affinity Capture-MS: 248
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 50
  • Co-crystal Structure: 1
  • Co-purification: 5
  • PCA: 2
  • Reconstituted Complex: 8

Genetic Interactions

  • Dosage Growth Defect: 1
  • Negative Genetic: 344
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 10
  • Positive Genetic: 56
  • Synthetic Growth Defect: 12
  • Synthetic Lethality: 9
  • Synthetic Rescue: 2
Regulation Details


The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.

SUS1 promoter is bound by Bur6p, Tfc7p, and Xbp1p in response to heat
Expression Details


Expression data are derived from records contained in the Gene Expression Omnibus (GEO), and are first log2 transformed and normalized. Referenced datasets may contain one or more condition(s), and as a result there may be a greater number of conditions than datasets represented in a single clickable histogram bar. The histogram division at 0.0 separates the down-regulated (green) conditions and datasets from those that are up-regulated (red). Click "Expression Details" to view all expression annotations and details for this locus, including a visualization of genes that share a similar expression pattern.

Literature Details


All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details" to view all literature information for this locus, including shared literature between genes.