Complex: ATR-ATRIP DNA damage-sensing kinase complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-3621
- Systematic Name
- 2xLCD1:2xMEC1
- SGD ID
- SGD:S000229699
- Aliases
- MEC1-DDC2 complex
- Description
- Master regulator of the DNA damage response controlling a signaling cascade required for the maintenance of genomic integrity. Activated by RPA complex (CPX-21)-coated single-stranded DNA at the site of DNA double-strand breaks and stalled replication forks. Appears to control the production of an adequate and balanced pool of deoxyribonucleotides and maintain replication fork stability.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
PDB Structure
When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.
| 5X6O |
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables protein serine/threonine kinase activity (IDA)
- Biological Process
-
- involved in nucleobase-containing compound metabolic process (BSR)
- involved in regulation of double-strand break repair (BSR)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Feng W (2016) Mec1/ATR, the Program Manager of Nucleic Acids Inc. Genes (Basel) 8(1) PMID: 28036033
Resources
IntAct | ModelArchive | PDB:5X6O ... Show all Show fewer