YRR1 / YOR162C Overview
- Standard Name
- YRR1 1
- Systematic Name
- YOR162C
- SGD ID
- SGD:S000005688
- Aliases
- PDR2 6 7
- Feature Type
- ORF , Verified
- Description
- Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication 1 2 3 4 5
- Name Description
- Yeast Reveromycin-A Resistant 1
- Paralog
- PDR8 5
- Comparative Info
-
Sequence
The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C. Download DNA or protein sequence, view genomic context and coordinates. Click "Sequence Details" to view all sequence information for this locus, including that for other strains.
- Summary
- YRR1 has a paralog, PDR8, that arose from the whole genome duplication
Analyze Sequence
S288C only
BLASTN | BLASTP | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species
BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi
S288C vs. other strains
Protein
Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein.
- Length (a.a.)
- 810
- Mol. Weight (Da)
- 92475.9
- Isoelectric Point
- 8.3
- Median Abundance (molecules/cell)
- 622 +/- 404
Alleles
Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results.
View all YRR1 alleles in SGD search
Gene Ontology
GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.
- Summary
- Sequence specific DNA-binding RNA polymerase II transcription factor, activates genes involved in oxidative stress response; localizes to the nucleus
View computational annotations
Molecular Function
- Manually Curated
Biological Process
- Manually Curated
- involved in cellular response to oxidative stress (IGI, IDA, IMP)
- involved in positive regulation of transcription by RNA polymerase II (IDA)
- involved in regulation of transcription by RNA polymerase II (IDA, IGI, IMP)
Phenotype
Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.
- Summary
- Non-essential gene; null mutants exhibit abnormal vacuolar morphology, defective respiratory metabolism, and impaired use of glutamine as a nitrogen source; overexpression impairs vegetative growth and enhances pseudohyphal growth
Classical Genetics
- null
- reduction of function
- gain of function
- unspecified
- null
- chemical compound accumulation: abnormal
- chemical compound accumulation: decreased
- chemical compound accumulation: increased
- competitive fitness: increased
- resistance to chemicals: decreased
- resistance to chemicals: increased
- resistance to chemicals: normal
- utilization of nitrogen source: decreased rate
- vacuolar morphology: abnormal
- viable
- overexpression
Large-scale Survey
Interaction
Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.
- Summary
- The yrr1 null mutant is viable; the null mutant of paralog pdr8 is viable; the yrr1 pdr8 double mutant has not been annotated for phenotype.
46 total interactions for 43 unique genes
Physical Interactions
- Affinity Capture-MS: 3
- Affinity Capture-RNA: 4
- Affinity Capture-Western: 1
- Biochemical Activity: 6
- Co-localization: 1
- PCA: 2
- Proximity Label-MS: 2
- Reconstituted Complex: 2
- Two-hybrid: 2
Genetic Interactions
- Dosage Growth Defect: 2
- Dosage Lethality: 1
- Negative Genetic: 13
- Phenotypic Enhancement: 1
- Phenotypic Suppression: 1
- Positive Genetic: 5
Regulation
The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.
- Summary
- YRR1 encodes a transcription factor that is a member of the C6 zinc finger class, containing a DNA binding domain also known as the Zn2Cys6 binuclear zinc cluster or zinc knuckle. Active as a homodimer, Yrr1p binds to Yrr1p response elements (YRREs) upstream of its target genes. Yrr1p has an important role in drug resistance, via upregulation of genes encoding drug efflux pumps such as the ATP-binding cassette transporters Snq2p and Yor1p and the major facilitator superfamily transporter Flr1p. YRR1 transcription is autoregulated, and Yrr1p activity is negatively regulated, apparently at a post-transcriptional level, by its paralog Yrm1p.
Expression
Expression data are derived from records contained in the Gene Expression Omnibus (GEO), and are first log2 transformed and normalized. Referenced datasets may contain one or more condition(s), and as a result there may be a greater number of conditions than datasets represented in a single clickable histogram bar. The histogram division at 0.0 separates the down-regulated (green) conditions and datasets from those that are up-regulated (red). Click "Expression Details" to view all expression annotations and details for this locus, including a visualization of genes that share a similar expression pattern.
Literature
All manually curated literature for the specified gene, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review). Click "Literature Details" to view all literature information for this locus, including shared literature between genes.