Gene Ontology Help

Separase-Securin complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Regulates the metaphase-to-anaphase transition during cell cycle progression, playing a role in control of the metaphase-anaphase transition and anaphase onset. Complex formation both activates and inhibits the protease activity of separase which is responsible for cleaving the MCD1/SCC1 (Q12158) subunit of the cohesin ring that holds sister chromatids together during mitosis. Securin appears to ensure that separase adopts its proper fold required for proteolytic activity and also promotes subcellular localization of separase to the nucleus. Securin is degraded via ubiquitylation by the anaphase-promoting complex (APC, CPX-760, CPX-761, CPX-762, CPX-756) enabling separase to become fully active.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

regulation of cell cycle, regulation of organelle organization, nucleus, organelle