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Nuclear pore complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
The nuclear pore complex (NPC) is a large assembly embedded in the nuclear envelope of eukaryotic cells. The yeast nucleus contains approximately 200 NPCs per cell and as the sole site of macromolecular traffic between the nucleus and cytoplasm, the complex provides an important control point for the regulation of gene expression. Inert polymers and small proteins less than 9 nm in diameter or less than 30-40 kDa in mass can freely diffuse through the NPC, larger particles traverse the NPC by a facilitated mechanism with the structure able to expand radially to accommodate the passage of larger particles. The nuclear basket subunits play an active role in transcription, transcriptional memory and chromatin organization by recruiting members of the transcription machinery to the nuclear side of the NCP.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

nuclear transport, nucleocytoplasmic transport, transport, nuclear envelope

Biological Process

Manually curated GO annotations reflect our best understanding of the basic biological process for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

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Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Cellular Component

Manually curated GO annotations reflect our best understanding of the basic cellular component for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.