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Gene Ontology Help

Nuclear cap-binding complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (mRNAs and pre-miRNAs). Required for processes such as pre-mRNA splicing through commitment complex and spliceosome formation, export of mRNA out of the nucleus in association with NPL3 (Q01560), degradation of nuclear mRNAs, primary miRNA processing and miRNA-mediated RNA interference. In the cytosol, importin-beta interacts with CBC-bound importin-alpha (CPX-1068) and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

RNA binding, mRNA binding, DNA-templated transcription, RNA catabolic process, RNA splicing, biosynthetic process, catabolic process, mRNA processing, nuclear transport, nucleobase-containing compound catabolic process, nucleobase-containing compound transport, nucleocytoplasmic transport, response to osmotic stress, response to stress, transcription by RNA polymerase II, transport, nucleus, organelle

Biological Process

Manually curated GO annotations reflect our best understanding of the basic biological process for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

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Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Molecular Function

Manually curated GO annotations reflect our best understanding of the basic molecular function for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Cellular Component

Manually curated GO annotations reflect our best understanding of the basic cellular component for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.