About SGD

The Saccharomyces Genome Database (SGD) provides comprehensive integrated biological information for the budding yeast Saccharomyces cerevisiae along with search and analysis tools to explore these data, enabling the discovery of functional relationships between sequence and gene products in fungi and higher organisms.

Meetings

Yeast Lipid Conference
June 01 to June 03, 2022 -

Chalmers University of Technology, Gothenburg, Sweden

Yeast ORFan Gene Project Summer Workshop
June 13 to June 18, 2022 -

Ohlone College, Newark CA

CNRS Workshop Conference, Gene transcription in yeast: From single molecules to separated phases
June 25 to June 30, 2022 -

Hotel Eden Roc, Sant Feliu de Guíxols, Spain

36th International Specialised Symposium on Yeasts (ISSY36): Yeast in the Genomics Era
July 12 to July 15, 2022 -

University of British Columbia, Vancouver, BC

The Yeast Chromosome Biology and Cell Cycle Conference
July 17 to July 21, 2022 -

Southbridge, MA

CSHL Yeast Genetics & Genomics course
July 26 to August 15, 2022 -

Cold Spring Harbor Laboratory, New York

Yeast Genetics Meeting 2022
August 17 to August 21, 2022 -

University of California, Los Angeles

Fungal Pathogen Genomics
May 07 to May 12, 2023 -

Wellcome Genome Campus, Hinxton, Cambridge, UK

New & Noteworthy

New Yeast-Based Assay for Classifying BRCA1 Variants - May 13, 2022

Lifetime risk of developing ovarian or breast cancer is increased by germline mutations in the BRCA1 gene. While specific pathogenic variants have been well studied, new sequencing technologies continue to identify variants of uncertain significance (VUS). These variants are comparatively rare and cannot easily be studied in humans. Thus, a recent study in the International […]

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Role of Npl3p in regulating senescence rates - May 06, 2022

Telomeres, regions of repetitive DNA at the terminal ends of linear chromosomes, function as protective caps essential to maintain chromosomal structural integrity. Telomeres shorten with every cell cycle and eventually activate replicative senescence (a checkpoint-mediated cell cycle arrest) once they reach a critical length. Regulation of telomere length is essential as an uncontrolled shortening of […]

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Degradation of Mmr1 protein vital for mitochondrial dynamics - April 29, 2022

Regulating mitochondrial dynamics during cell division is crucial for maintaining homeostasis in eukaryotic cells. In budding yeast, proteins such as Myo2p and Mmr1p are essential to transport mitochondria into the growing bud, which post cell division, exists as an independent daughter cell. Improper inheritance and/or distribution of mitochondria can generate reactive oxygen species (ROS) toxicity […]

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Yeast Lifespan Impacted by rDNA Copy Number - April 22, 2022

Replicative lifespan (RLS), determined by the number of daughter cells a mother cell produces before death, has proved to be an effective model for studying aging in budding yeast. The chromatin-associated proteins Sir2p and Fob1p have been shown to modulate ribosomal DNA (rDNA) and impact the formation of extrachromosomal rDNA circles (ERCs), an accumulation of which is linked to […]

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Yeast Reveals an Alzheimer’s Clue - April 15, 2022

In a recent issue of EMBO Molecular Medicine, an intriguing study with potential implications for Alzheimer’s disease (AD) by Ring et al. used yeast to look at why human amyloid beta 42 (Abeta42) kills cells. Upon overexpression in yeast, human Abeta42 protein oligomerizes into aggregates that translocate to mitochondria, where the aggregates cause oxidative stress […]

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