The Saccharomyces Genome Database (SGD) provides comprehensive integrated biological information for the budding yeast Saccharomyces cerevisiae along with search and analysis tools to explore these data, enabling the discovery of functional relationships between sequence and gene products in fungi and higher organisms.
Chalmers University of Technology, Gothenburg, Sweden
Hotel Eden Roc, Sant Feliu de Guíxols, Spain
University of British Columbia, Vancouver, BC
Cold Spring Harbor Laboratory, New York
Wellcome Genome Campus, Hinxton, Cambridge, UK
Lifetime risk of developing ovarian or breast cancer is increased by germline mutations in the BRCA1 gene. While specific pathogenic variants have been well studied, new sequencing technologies continue to identify variants of uncertain significance (VUS). These variants are comparatively rare and cannot easily be studied in humans. Thus, a recent study in the International […]
Read MoreTelomeres, regions of repetitive DNA at the terminal ends of linear chromosomes, function as protective caps essential to maintain chromosomal structural integrity. Telomeres shorten with every cell cycle and eventually activate replicative senescence (a checkpoint-mediated cell cycle arrest) once they reach a critical length. Regulation of telomere length is essential as an uncontrolled shortening of […]
Read MoreRegulating mitochondrial dynamics during cell division is crucial for maintaining homeostasis in eukaryotic cells. In budding yeast, proteins such as Myo2p and Mmr1p are essential to transport mitochondria into the growing bud, which post cell division, exists as an independent daughter cell. Improper inheritance and/or distribution of mitochondria can generate reactive oxygen species (ROS) toxicity […]
Read MoreReplicative lifespan (RLS), determined by the number of daughter cells a mother cell produces before death, has proved to be an effective model for studying aging in budding yeast. The chromatin-associated proteins Sir2p and Fob1p have been shown to modulate ribosomal DNA (rDNA) and impact the formation of extrachromosomal rDNA circles (ERCs), an accumulation of which is linked to […]
Read MoreIn a recent issue of EMBO Molecular Medicine, an intriguing study with potential implications for Alzheimer’s disease (AD) by Ring et al. used yeast to look at why human amyloid beta 42 (Abeta42) kills cells. Upon overexpression in yeast, human Abeta42 protein oligomerizes into aggregates that translocate to mitochondria, where the aggregates cause oxidative stress […]
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