About SGD

The Saccharomyces Genome Database (SGD) provides comprehensive integrated biological information for the budding yeast Saccharomyces cerevisiae along with search and analysis tools to explore these data, enabling the discovery of functional relationships between sequence and gene products in fungi and higher organisms.

Meetings

Fungal Pathogen Genomics
May 07 to May 12, 2023 -

Wellcome Genome Campus, Hinxton, Cambridge, UK

TAGC2024 The Allied Genetics Conference
March 05 to March 10, 2024 -

National Harbor | Washington DC Metro Area

New & Noteworthy

Role of Sumoylation in Regulating Replication - September 09, 2022

There are ~400 origins of replication in yeast, each of which can be “licensed” by the binding of the conserved origin recognition complex (ORC) and then the MCM replicative helicase complex, all of which happens in G1 phase. During the subsequent S phase, origins are then “activated” by binding of several other replication factors, leading […]

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Humanizing Glycolysis in Yeast - September 02, 2022

While glycolysis is highly conserved between unicellular yeast and multicellular humans, it appears that not only the glycolytic functions but also the secondary (aka “moonlighting”) functions of the relevant proteins remain largely consistent. This consistency presents unique opportunities for better understanding human glycolysis in muscle tissue and elsewhere. The technical challenges of studying glycolytic enzymes […]

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Link Between Aging and Iron - August 25, 2022

Perturbations in iron homeostasis affect aging, but how this happens has remained a bit of a black box. A new study by Patnaik et al. in Cell Reports illuminates this box by looking more closely at the transcription factors that are first to respond when iron becomes limiting. Key among these are Atf1p and Atf2p, […]

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Sen1p Is the Traffic Cop for RNA Polymerase III - August 12, 2022

One way to imagine DNA is as a busy road with a lot of competing traffic. Say, a small village in southern Italy…where someone must mediate conflicts between competing vehicles to avoid disaster. It turns out that the “someone” in yeast cells is Sen1p. Two recent papers from associated groups describe the intriguing detail of […]

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A Redox Switch that Remakes a Guide Protein into an Antioxidant - August 05, 2022

Cells are efficient machines, honed by selection. Recent studies are showing us how cells are more efficient than we realized, with proteins discovered to have multiple functions that can be surprisingly different under changes in environment. A new paper in Molecular Cell describes Get3p as one such protein. Under non-stress conditions, Get3p acts as an […]

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