Complex: RPD3L histone deacetylase complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-1852
- Systematic Name
- ASH1:CTI6:DEP1:PHO23:RPD3:RXT2:RXT3:SAP30:SDS3:SIN3:UME1:UME6
- SGD ID
- SGD:S000218003
- Aliases
- RPD3(L) ; RPD3/SIN3 large histone deacetylase complex ; RPD3L complex
- Description
- Histone deacetylase recruited to promoters in association with specific transcription factors such as UME6 (P39001), ASH1 (P34233), IME1 (P21190), WHI5 (Q12416), and STB1 (P42845) where it acts as a promoter targeted regulator of transcription.. At the promoter region, RPD3 deacetylates specific lysine residues on histones H3 and H4 in a localized region spanning about two nucleosomes. May also act to promote nucleosome assembly like a histone chaperone and prevent RSC-dependent histone eviction from nucleosomes. During vegetative growth, the complex functions as a negative regulator for all genes, whereas upon nitrogen depletion it functions as a positive regulator early during meiosis.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables histone deacetylase activity (BSR)
- enables histone deacetylase activity (BSR)
- enables transcription coregulator activity (BSR)
- Biological Process
-
- acts upstream of or within cohesin loading (IDA)
- involved in nucleosome assembly (BSR)
- involved in regulation of transcription by RNA polymerase II (BSR)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Patel AB, et al. (2023) Cryo-EM structure of the Saccharomyces cerevisiae Rpd3L histone deacetylase complex. Nat Commun 14(1):3061 PMID: 37244892
- Chen XF, et al. (2012) The Rpd3 core complex is a chromatin stabilization module. Curr Biol 22(1):56-63 PMID: 22177115
Resources
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