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Complex: ISW1a chromatin remodeling complex

Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.

Curated by
IntAct
ComplexAc
CPX-637
Systematic Name
IOC3:ISW1
SGD ID
SGD:S000217880
Aliases
ISW1a chromatin-remodeling complex. ; ISW1a complex ; Imitation switch complex 1a
Description
ATP-dependent chromatin remodeling complex which modulates the structure of chromatin to regulate a variety of cellular processes, including DNA replication, repair, chromosome segregation and transcription. Slides mononucleosomes from the end to the center of DNA and requires the flexible, acidic patch of the histone H4 tail to efficiently dock its translocase on the nucleosome, for stimulating the ATPase activity and inducing nucleosome mobility. Positions histone octamers in dinucleosomes more specifically than in mononucleosomes. Regularly spaces nucleosomes in vitro every 175 bp. ISW1a bound to 33 bp of extranucleosomal DNA at both entry/exit sites is in an inactive conformation, it becomes activated on binding to extranucleosomal DNA at only one entry/exit site. ISW1a bound to only one extranucleosomal DNA makes a stable contact with nucleosomal DNA two helical turns from the dyad axis, and this interaction is lost when ISW1a is bound to extranucleosomal DNA at both entry/exit sites. Required for the transcriptional repression of a number of genes, this set differs from those repressed by ISW1b (CPX-636) with which it shares a catalytic subunit.

Complex Diagram

This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.

PDB Structure

When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. Click on the image or link for further information about the physical structure.

2Y9Y 2Y9Y

Subunits

This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.

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Subunit Description Stoichiometry

Gene Ontology

Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.

Shared Annotations

This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.

References

List of references used specifically to curate the information on this page.

External Identifiers

IntEnz: 3.6.1

Resources

IntAct | ModelArchive | PDB:2Y9Y