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Gene Ontology Term: IRE1-mediated unfolded protein response

GO ID
GO:0036498
Aspect
Biological Process
Description
The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.
Synonyms
endoplasmic reticulum unfolded protein response; IRE1 signaling, ERN1-mediated unfolded protein response, inositol-requiring enzyme 1-mediated unfolded protein response, inositol-requiring transmembrane kinase/endonuclease signal transduction, IRE1 branch of UPR, IRE1 signal transduction pathway, IRE1 signaling in response to endoplasmic reticulum stress, IRE1alpha unfolded protein response, IRE1p unfolded protein response, UPR signaling by IRE1 stress sensor
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Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

High-throughput

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Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference

Computational

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Gene/Complex Qualifier Gene Ontology Term Aspect Annotation Extension Evidence Method Source Assigned On Reference