AboutBlogDownloadExploreHelpGet Data

Reference: Sanchez Y, et al. (1996) Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271(5247):357-60

Reference Help

Abstract

Mutants of the Saccharomyces cerevisiae ataxia telangiectasia mutated (ATM) homolog MEC1/SAD3/ESR1 were identified that could live only if the RAD53/SAD1 checkpoint kinase was overproduced. MEC1 and a structurally related gene, TEL1, have overlapping functions in response to DNA damage and replication blocks that in mutants can be provided by overproduction of RAD53. Both MEC1 and TEL1 were found to control phosphorylation of Rad53p in response to DNA damage. These results indicate that RAD53 is a signal transducer in the DNA damage and replication checkpoint pathways and functions downstream of two members of the ATM lipid kinase family. Because several members of this pathway are conserved among eukaryotes, it is likely that a RAD53-related kinase will function downstream of the human ATM gene product and play an important role in the mammalian response to DNA damage.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, P.H.S.
Authors
Sanchez Y, Desany BA, Jones WJ, Liu Q, Wang B, Elledge SJ
Primary Lit For
TEL1 | MEC1 | RAD53

Regulation Annotations 2 entries for 3 genes

Increase the total number of rows displayed on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; to filter the table by a specific experiment type, type a keyword into the Filter box (for example, “microarray”); download this table as a .txt file using the Download button or click Analyze to further view and analyze the list of target genes using GO Term Finder, GO Slim Mapper, or SPELL.

RegulatorTargetDirectionRegulation OfHappens DuringMethodEvidence
TEL1RAD53protein activityDNA damage responsemanually curatedqualitative western immunoblotting evidence
MEC1RAD53protein activityDNA damage responsemanually curatedqualitative western immunoblotting evidence
Showing 1 to 2 of 2 entries