Reference: Redd MJ, et al. (1997)
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Abstract
The Saccharomyces cerevisiae Tup1 protein is a member of a family of WD repeat containing proteins that are involved in repression of transcription. Tup1, along with the Ssn6 protein, represses a wide variety of genes in yeast including cell type-specific and glucose-repressed genes. Tup1 and Ssn6 are recruited to these specific gene sets by interaction with sequence-specific DNA binding proteins. In this work, a protein complex containing Ssn6 and Tup1 was purified to determine its composition. The size of the complex is estimated to be 440 kDa. Tup1 and Ssn6, which are both phosphoproteins, are the only proteins present in stoichiometric amounts in the complex. We also demonstrate that this purified complex represses transcription in an in vitro assay.
- Reference Type
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Journal Article
- Authors
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Redd MJ,
Arnaud MB,
Johnson AD
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- CYC8 | TUP1 | CYC8-TUP1 corepressor complex
Gene Ontology Annotations
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| Evidence ID |
Analyze ID |
Gene |
Gene Systematic Name |
Phenotype |
Experiment Type |
Experiment Type Category |
Mutant Information |
Strain Background |
Chemical |
Details |
Reference |
Disease Annotations
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Analyze ID |
Gene |
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Disease Ontology Term |
Disease Ontology Term ID |
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Source |
Assigned On |
|
Reference |
Regulation Annotations
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Analyze ID |
Regulator |
Regulator Systematic Name |
Target |
Target Systematic Name |
Direction |
Regulation of |
Happens During |
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Regulation Of |
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Post-translational Modifications
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Analyze ID |
|
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Interactor |
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| Interactor | Interactor | Assay | Annotation | Action | Modification |
|---|
| CYC8 | TUP1 | Co-fractionation | manually curated | Hit-Bait | No Modification |
Functional Complementation Annotations
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Locus ID |
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Species |
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Details |
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Reference |