What determines how long an animal can live? Some have argued that the life-span of a species is limited by a fixed total metabolic potential that is consumed over a lifetime. This follows from the observation that smaller animals have faster metabolic rates and generally shorter life-spans. Consistent with this idea, rats or mice that have existed on a diet reduced in calories live longer than animals that were allowed to eat as much as they liked. A corollary of this view is that the "clock" that times aging might be cumulative damage that is generated by toxic by-products of metabolism, such as oxygen radicals. Others have suggested that life-span may be genetically determined and that these genetic factors override any simple metabolic readout. This could explain why bats and mice, mammals of roughly the same size, have life-spans that differ by a factor of 5 to 10. This view also suggests that the clock is a genetic program set at a different rate in each species. The cloning and sequencing of the clk-1 gene of Caenorhabditis elegans reported in this issue, along with recent findings discussed below, suggests how
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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