Reference: Watkins NJ, et al. (2000)
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Abstract
The box C/D snoRNAs function in directing 2'-O-methylation and/or as chaperones in the processing of ribosomal RNA. We show here that Snu13p (15.5 kD in human), a component of the U4/U6.U5 tri-snRNP, is also associated with the box C/D snoRNAs. Indeed, genetic depletion of Snu13p in yeast leads to a major defect in RNA metabolism. The box C/D motif can be folded into a stem-internal loop-stem structure, almost identical to the 15.5 kD binding site in the U4 snRNA. Consistent with this, the box C/D motif binds Snu13p/ 15.5 kD in vitro. The similarities in structure and function observed between the U4 snRNP (chaperone for U6) and the box C/D snoRNPs raises the interesting possibility that these particles may have evolved from a common ancestral RNP.
- Reference Type
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Journal Article |
Research Support, Non-U.S. Gov't
- Authors
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Watkins NJ,
Ségault V,
Charpentier B,
Nottrott S,
Fabrizio P,
Bachi A,
Wilm M,
Rosbash M,
Branlant C,
Lührmann R
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