Marchfelder U, et al. (2003)

Abstract

The proteins Sir2, Sir3 and Sir4 repress transcription of the silent mating-type loci HML and HMR and of reporter genes inserted at telomeres. Previous microarray analyses suggested that additional non-telomeric genes exist which are repressed by the Sir proteins. In this study, we tested the expression of 12 such genes by Northern analysis and RT-PCR. However, we were unable to verify their SIR-dependent regulation, which suggests that SIR-mediated repression may be restricted to the known repressed regions.

PMID: 12845605
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Reference Type: Journal Article | Research Support, Non-U.S. Gov't
Authors: Marchfelder U, Rateitschak K, Ehrenhofer-Murray AE
Primary Lit For: SIR4 | SIR2 | SIR3 | USV1
Additional Lit For: HIT1 | ZRT1 | BNA1 | MTH1 | PEX17 | NUF2 | CRC1 | CTF13 | SNO1 | SNZ1 | LTV1 ... Show all Show fewer
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