Maloisel L, et al. (2004)

Abstract

A screen for mutants of budding yeast defective in meiotic gene conversion identified a novel allele of the POL3 gene. POL3 encodes the catalytic subunit of DNA polymerase delta, an essential DNA polymerase involved in genomic DNA replication. The new allele, pol3-ct, specifies a protein missing the last four amino acids. pol3-ct shows little or no defect in DNA replication, but displays a reduction in the length of meiotic gene conversion tracts and a decrease in crossing over. We propose a model in which DNA synthesis determines the length of strand exchange intermediates and influences their resolution toward crossing over.

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Reference Type: Comparative Study | Journal Article | Research Support, Non-U.S. Gov't
Authors: Maloisel L, Bhargava J, Roeder GS
Primary Lit For: POL3 | DNA polymerase delta complex
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