Chadick JZ and Asturias FJ (2005)

Abstract

Mediator, a macromolecular complex comprising approximately 20 different protein components, is largely responsible for the tight control of transcription that underpins cell development, differentiation, and maintenance in eukaryotes from yeast to human. In the past five years, macromolecular electron microscopy has been used to characterize the structure of Mediator, and of the complexes it forms with other components of the transcription machinery. The results reveal how Mediator interacts with RNA polymerase II, and suggest that regulatory information could be conveyed through changes in Mediator conformation that would influence the transcription initiation process.

PMID: 15896745
DOI full text
PubMed
PubTator

Download Citation (.nbib)

Reference Type: Journal Article | Research Support, Non-U.S. Gov't | Review
Authors: Chadick JZ, Asturias FJ
Primary Lit For: DNA-directed RNA polymerase II complex
Additional Lit For: ROX3 | SRB7 | MED6 | SIN4 | SRB4 | SRB5 | PGD1 | MED2 | SRB6 | NUT2 | CSE2 | ... Show all
Review For

Increase the total number of rows displayed on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; to filter the table by a specific experiment type, type a keyword into the Filter box (for example, “microarray”); download this table as a .txt file using the Download button or click Analyze to further view and analyze the list of target genes using GO Term Finder, GO Slim Mapper, or SPELL.

Interaction Annotations