Yeast, Saccharomyces cerevisiae, exposed to CdCl2 for 17 h was analysed with reference to survival, MTs and oxidative stress biomarkers. An enhanced accumulation of MDA and the increased activities of SOD and GPx in the Cd-treated yeasts under aerobic condition indicated CdCl2-caused oxidative stress in S. cerevisiae. MTs were significantly induced by CdCl2 under aerobic condition and the induced MTs contents were positively correlated with the accumulation of MDA in this study. However, MTs induction can be prominently inhibited by coincubation with NAC or anaerobic culture via eliminating ROS. This oxidative stress reduction was reflected by the decreases in MDA level and SOD and GPx activities. The results suggest that MTs inductive activity of cadmium in yeast cells was mediated by oxidative stress. In addition, increase of MTs contents was observed in cells untreated with CdCl2 under anaerobic conditions or coincubation with NAC, suggesting MTs are also susceptive to reductive stress.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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