Reference: Barz T, et al. (2003)
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Abstract
The budding yeast Saccharomyces cerevisiae encounters phosphate starvation by the transcription-regulated PHO pathway. We find that genetic perturbation of protein kinase CK2, a conserved tetrameric Ser/Thr phosphotransferase with links to cell cycle and transcription, affects expression of PHO pathway genes in a subunit- and isoform-specific manner. Remarkably, the genes encoding phosphate supplying phosphatases and transporters are significantly repressed, while the genes encoding components of the central pathway regulator complex, a cyclin-dependent kinase (CDK), a cyclin, and a CDK inhibitor, remain unaltered. Thus, perturbation of CK2 uncouples the executive part of the PHO pathway from its cyclin-CDK control complex.
- Reference Type
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Journal Article |
Research Support, Non-U.S. Gov't
- Authors
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Barz T,
Ackermann K,
Pyerin W
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- PHO4 | VTC4 | CKB1 | CKA1 | CKA2 | CKB2 | VTC3 | GDE1
- PHO3 | PHO5 | PHO89 | SPL2 | PHO11 | PHO12 | GPP2 | PHM6 | PHO84 | PHM7 | PHO8 ... Show all Show fewer
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| Interactor | Interactor | Assay | Annotation | Action | Modification |
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| CKA1 | PHO4 | Biochemical Activity | manually curated | Bait-Hit | phosphorylated residue |
| PHO4 | CKA2 | Biochemical Activity | manually curated | Hit-Bait | phosphorylated residue |
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