The tertiary structure of the eukaryotic ribosomal 5 S RNA was examined using ethylnitrosourea reactivity as a probe for phosphodiester bonds. In three different 5 S RNAs of diverse origin the reactivity was restricted to the same three regions of the sequence, corresponding to residues G 99-A 101, A 88-G 89, and G 75 in the rat 5 S RNA molecule. All of these restricted residues are in highly conserved sequences; five of the residues (G 75, G 89, G 99, A 100, and A 101 in the rat) are present in all 5 S RNAs. The results indicate that, as has been suggested for the secondary structure, the tertiary structure of the 5 S RNA is also highly conserved. Based on these data, a working model for the tertiary structure is suggested which is consistent with previous studies on the structure of the free RNA and 5 S RNA-protein complexes.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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