Keyes BE, et al. (2008)

Abstract

The anaphase promoting complex (APC) targets proteins for degradation to promote progression through the cell cycle. Here we show that Clb5, an APCCdc20 substrate, is degraded when the spindle checkpoint is active, while other APCCdc20 substrates are stabilized, suggesting that APCCdc20 inhibition by the spindle checkpoint is substrate specific.

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Reference Type: Journal Article
Authors: Keyes BE, Yellman CM, Burke DJ
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