Reference: Yoshitani A, et al. (2008) The yeast checkpoint kinase Dun1 downregulates DIN7 in the absence of DNA damage. Biosci Biotechnol Biochem 72(6):1630-4

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Abstract


Yeast DIN7 is a DNA damage-inducible gene. Its expression is increased in the absence of Dun1, a DNA damage checkpoint kinase. We identified a DIN7 promoter region responsible for Dun1-mediated downregulation and found that DIN7 expression was not further increased in response to hydroxyurea in Deltadun1 cells. Thus DIN7 repression by Dun1 can be released upon DNA damage.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Yoshitani A, Ling F, Yoshida M
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