Identifying the genetic basis of natural variation in genome-wide gene expression is a daunting task, yet central to characterizing the potential evolutionary impact of gene expression polymorphism. In this issue, Brown et al. reveal the genetic variation that underlies a significant portion of the gene expression polymorphism that segregates in a natural isolate of the wine and bread yeast Saccharomyces cerevisiae. That polymorphism is shown to be associated with a single nucleotide insertion. Interestingly, the major expression polymorphism is not caused by an insertion in a cis-regulatory region or in a transcription factor, but in a homonucleotide repeat within the coding sequence of SSY1, which encodes an amino acid sensor. The expression polymorphism, perhaps unsurprisingly, is also environment-dependent and leads to differential fitness across environments. The result calls for a deeper consideration within molecular ecological genomics of the gene-by-environment interactions that lead to differential gene expression. The finding also calls for further data, clarifying the kinds of genetic variation that constitute gene expression polymorphism between individuals in natural populations.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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