The Candida albicans genome encodes four chitinases, CHT1, CHT2, CHT3 and CHT4. All four C. albicans chitinase-encoding genes are non-essential. The corresponding proteins belong to two groups in which Cht1, Cht2 and Cht3 are more similar to Saccharomyces cerevisiae Cts1, while Cht4 is more similar to ScCts2. In the filamentous fungus Ashbya gossypii, a CTS2 homolog (ACL166w) was identified as the sole chitinase gene. The AgCts2 is 490 aa in Length and shows 42.3% overall identity to ScCts2 (511 aa) and 33.2% identity to CaCht4 (388 aa). The A. gossypii cts2 deletion mutant showed no growth retardation or vegetative morphogenetic defects. However, upon sporulation Agcts2 mutants revealed a defect in spore formation. Expression of AgCts2 using a lacZ reporter gene was only found in the centre of a mycelium corresponding to the sporogenous part of a colony. The mutant spore phenotype of Agcts2 could be complemented by either AgCTS2, the S. cerevisiae CTS2, or the C. albicans CHT4 gene when expressed by either the AgCTS2 or the AgTEF1 promoter.
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Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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Site | Modification | Modifier | Source | Reference |
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Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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