Silencing of genomic regions in eukaryotes is thought to be the result of transcriptional repression. Recent results show that nuclear RNA degradation plays a major role in discarding RNA molecules with no obvious roles that are produced by cryptic RNA polymerase II transcription throughout the Saccharomyces cerevisiae genome. These cryptic transcripts are polyadenylated at their 3'-end by a poly(A) polymerase complex distinct from that used by the mRNA factory, which serves to tag these aberrant transcripts for nuclear degradation.

• PMID: 16243527
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Reference Type

Journal Article | Research Support, N.I.H., Extramural

Authors

Chanfreau GF

Primary Lit For

DNA-directed RNA polymerase II complex

Additional Lit For

Review For