Reference: Yang D, et al. (2004) Synthesis of Chiral beta 3-aminoxy peptides. J Org Chem 69(22):7577-81

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Abstract


A series of chiral beta(3)-aminoxy acids or amides with various side chains have been synthesized via two different approaches. One is the Arndt-Eistert homologation approach, using chiral alpha-aminoxy acids as starting materials. The other approach, utilizing the enantioselective reduction of beta-keto esters catalyzed by baker's yeast or chiral Ru(II) complexes, produces chiral beta(3)-aminoxy acids with nonproteinaceous side chains. The oligomers of beta(3)-aminoxy acids can be readily prepared using EDCI/HOAt as the coupling reagent.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Yang D, Zhang YH, Li B, Zhang DW
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