Numerous observations support the existence of senescence factors in yeast. Historically, the asymmetric propagation and accumulation of extra-chromosomal ribosomal DNA circles (ERCs) has been proposed to fulfill this function. On the other hand, several recent papers have re-invigorated the discussion of a potential role for cell size and/or hypertrophy in yeast senescence. While studies have revealed evidence both in favor of and against the hypertrophy model, the prevalent dogma largely discounts a potential role for cell size in the control of cellular lifespan. However, new results not only demonstrate a correlation between cell size and senescence, but allude to a causative role of cell size and hypertrophy in aging. In particular, the degree of hypertrophy, as determined by the rate of cell growth per generation, appears to function as a major determinant of cellular lifespan. Herein, in light of these new data, we examine the recent debate regarding a potential role for cell size in yeast aging, address criticisms of this model, and suggest that the balance is tipping in favor of hypertrophy having a causative role in aging, albeit not as the sole “aging factor.”
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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