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Reference: Baichwal VR, et al. (1983) Leucine biosynthesis in yeast : Identification of two genes (LEU4, LEU5) that affect α-Isopropylmalate synthase activity and evidence that LEU1 and LEU2 gene expression is controlled by α-Isopropylmalate and the product of a regulatory gene. Curr Genet 7(5):369-77

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Abstract

Tetrad analysis indicates that α-isopropylmalate synthase activity of yeast is determined by two separate genes, designated LEU4 and LEU5. LEU4 is identified as a structural gene. LEU5 either encodes another α-isopropylmalate synthase activity by itself or provides some function needed for the expression of a second structural gene. The properties of mutants affecting the biosynthesis of leucine and its regulation suggest that the expression of LEU1 and LEU2 (structural genes encoding isopropylmalate isomerase and β-isopropylmalate dehydrogenase, respectively) is controlled by a complex of a-isopropylmalate and a regulatory element (the LEU3 gene product). Similarities and differences between yeast and Neurospora crassa with respect to leucine biosynthesis are discussed.

Reference Type
Journal Article
Authors
Baichwal VR, Cunningham TS, Gatzek PR, Kohlhaw GB
Primary Lit For
LEU2 | LEU1 | LEU3 | LEU4 | U4 small nuclear ribonucleoprotein complex
Additional Lit For
LEU5 | leu3-781