Reference: Toda T, et al. (2020) ROS-mediated synthetic growth defect caused by impaired metabolism of sphingolipids and phosphatidylserine in budding yeast. Biosci Biotechnol Biochem 84(12):2529-2532

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Abstract


Previously, we found that yeast exhibits a strong growth defect with the combination of a lack of gene involved in structural modification of sphingolipids and repression of the phosphatidylserine synthase gene. Here we found that the double gene mutation causes reactive oxygen species-mediated cell growth defect, which is suppressed by deletion of LEM3 encoding the subunit of phospholipid flippase.

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Journal Article
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Toda T, Urita A, Koga A, Takayama C, Tani M
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