The cells of Saccharomyces cerevisiae are capable for phosphate surplus: the increased uptake of phosphate (Pi) and accumulation of inorganic polyphosphate (polyP) occur when the cells after Pi limitation were cultivated in a medium supplemented with Pi. We demonstrated that single knockout mutations in the PHO84, PHO87, and PHO89 genes encoding plasma membrane phosphate transporters suppressed the Pi uptake and polyP accumulation under phosphate surplus at nitrogen starvation. The knockout strains in the PHM6 and PHM7 genes encoding unannotated PHO-proteins showed decreased polyP accumulation under Pi surplus both at nitrogen starvation and in complete YPD medium. This is due to the suppression of Pi uptake in the cells of these mutant strains. We speculate that Pi transporters of plasma membrane, and Phm6 and Phm7 proteins function in concert providing increased Pi uptake at phosphate surplus conditions.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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