Reference: Soffers JHM and Workman JL (2020) The SAGA chromatin-modifying complex: the sum of its parts is greater than the whole. Genes Dev 34(19-20):1287-1303

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Abstract


There are many large protein complexes involved in transcription in a chromatin context. However, recent studies on the SAGA coactivator complex are generating new paradigms for how the components of these complexes function, both independently and in concert. This review highlights the initial discovery of the canonical SAGA complex 23 years ago, our evolving understanding of its modular structure and the relevance of its modular nature for its coactivator function in gene regulation.

Reference Type
Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Review
Authors
Soffers JHM, Workman JL
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