Reference: Hu K and Cao Y (2024) Ping, pong, and freeze: Structural insights into the inhibition of ceramide synthase by Fumonisin B1. Structure 32(9):1296-1298

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Abstract


Fumonisin B1 (FB1) targets sphingolipid biosynthesis, inhibiting ceramide synthases. In this issue of Structure, Zhang et al.1 determined the cryoelectron microscopic structures of yeast ceramide synthase in complex with FB1 and its acylated derivative, acyl-FB1, revealing a two-step "ping-pong" mechanism for the N-acylation of FB1 and how it inhibits ceramide synthase.

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Journal Article
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Hu K, Cao Y
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