The key to healthy offspring production lies in the accurate inheritance of components from progenitor germ cells during gametogenesis. Along with genetic material, precise regulation of organelle inheritance is vital for gamete health and embryonic development, especially in aged organisms, where organelle function declines and damage accumulates. In these cases, removing age-related organellar defects in precursor cells is crucial for successful reproduction. The single-celled organism Saccharomyces cerevisiae shares striking similarities with more complex organisms: like metazoan cells, yeast accumulate organelle damage with age, yet can still produce damage-free gametes with a reset lifespan. Recent studies show that organelles undergo significant reorganization during yeast gametogenesis, and similar remodeling occurs in metazoans, suggesting common strategies for maintaining gamete quality. This review summarizes organellar reorganization during gametogenesis in yeast and how it aids in clearing age-related cellular damage. We also explore organellar remodeling in multicellular organisms and discuss the potential mechanisms and biological benefits of meiotic organellar reshaping.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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