Driven by consumer preferences for safety and environmental protection, the global cosmetics industry has an increasing demand for natural and sustainable ingredients. Saccharomyces cerevisiae has emerged as a powerful platform for the biosynthesis of cosmetic ingredients due to its strong metabolic capacity, genetic operability, and cost-effective production capabilities. This review focuses on the latest advances in S. cerevisiae for the production of high-value cosmetic compounds, including antioxidants, repair agents, moisturizers, and structure-maintaining ingredients. Key strategies, such as genetic and metabolic engineering, pathway modularity, and fermentation optimization, are discussed, demonstrating significant improvements in yield and efficiency. In addition, the integration of artificial intelligence and machine learning in strain design and process control is explored, providing promising solutions to overcome metabolic bottlenecks and scale up production. Despite challenges such as metabolic burden, S. cerevisiae shows great potential for sustainable and scalable biosynthesis of cosmetic ingredients, paving the way for the next generation of biobased cosmetics. This comprehensive review provides valuable insights and technical references for the development of the field of synthetic biology in the cosmetics industry.
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Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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Site | Modification | Modifier | Source | Reference |
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Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details about experiment type and any other genes involved in the interaction.
Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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