Oxidative stress, driven by the accumulation of reactive oxygen species (ROS), poses a significant challenge to the productivity and robustness of Saccharomyces cerevisiae in industrial applications. This review provides an overview of oxidative stress mechanisms, focusing on transcription factors (Yap1p, Skn7p, Msn2/4p) and their regulation through different stress signaling pathways such as HOG, CWI, TOR, and cAMP/PKA. Advanced strategies for enhancing oxidative stress resistance are discussed, including antioxidant enzyme overexpression, redox cofactor optimization, transcription factor modulation, and promoter engineering. Emerging tools like omics-guided gene discovery, biosensor-based feedback regulation, and machine learning-driven optimization are highlighted as promising approaches for constructing robust yeast cell factories. These insights pave the way for intelligent strain design to improve industrial performance under oxidative stress conditions.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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