Mitochondria are indispensable eukaryotic organelle required for diverse cellular functions. Mitochondrial health depends on the biogenesis of diverse mitochondrial proteins mediated by specialized protein transport machinery from outer and inner membranes called translocases. The carrier translocase (also known as Translocase of the inner membrane 22 (TIM22 complex)) is a unique evolutionary conserved protein translocation machinery involved in importing and integrating complex multispanning inner membrane proteins required for energy generation and cellular metabolic homeostasis. Recent studies have revealed novel characteristics of this machinery, particularly in the higher eukaryotes. In this review, we have discussed the recent advancements in the structure and function of the TIM22 complex in different eukaryotes, with a particular emphasis on the importance of the TIM22 complex in regulating mitochondrial health and pathophysiology.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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