Autophagy is a conserved degradation process delivering intracellular components to lysosomes or vacuoles. Yeast studies have been pivotal in identifying autophagy-related (ATG) genes and defining the core machinery essential for autophagosome formation. A recent comprehensive analysis that systematically examined all atg mutants in S. cerevisiae under autophagy-inducing conditions revealed that mutants lacking Atg13, Atg8-conjugation, or Atg12-conjugation components retain partial activity in certain autophagy-related pathways, indicating that these core factors are not strictly essential for autophagy in yeast. In this commentary, we summarize how recent findings reshape our understanding of the flexibility in the essentiality of core autophagy factors and discuss the emerging importance of protein interaction-driven feedback in autophagy regulation.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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