Eukaryotic transcription of mRNAs and some non-coding RNAs is governed by RNA Polymerase II (RNA pol II). The full progression of RNA pol II across a gene - from promoter clearance through transcript elongation and termination - is dependent upon the post-translational modifications (PTMs) of its carboxy-terminal domain (CTD) and the dynamic recruitment of numerous trans-acting factors. Rtr1 in yeast and its human orthologue, RPAP2, have emerged as multifunctional regulators of RNA pol II. Despite evidence supporting their role as Ser5-specific CTD phosphatases, structural and biochemical studies have raised doubts about whether they are bona fide phosphatases or instead function as cofactors that influence the activity of established CTD phosphatases. Furthermore, both proteins have been implicated in processes ranging from RNA pol II biogenesis and nuclear transport to transcriptional elongation and termination. Notably, Rtr1's influence also extends to post-transcriptional events like mRNA stability. In this review, we describe the main functions attributed to Rtr1 and RPAP2, and discuss the role of the human homologue in various diseases.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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