Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
35 entries for 16 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|---|
| FOB1 | chromosome/plasmid maintenance: decreased | heterozygous diploid | null Allele: fob1-Δ | Other | Details: >2-fold increase in the rate of chromosome loss, indicative of chromosome instability (CIN) | Strome ED, et al. (2008) PMID:18245329 | |
| FOB1 | chromosome/plasmid maintenance: decreased | classical genetics | null Allele: fob1-Δ | S288C | Details: reduction in rDNA copy number during long-term evolution experiments, with increased accumulation of extrachromosomal rDNA circles (ERCs) | Murai T, et al. (2024) PMID:38384843 | |
| FOB1 | chronological lifespan: decreased | competitive growth competitive survival of mixed stationary phase co-cultures | null Allele: fob1-Δ | S288C | Garay E, et al. (2014) PMID:24586198 | ||
| FOB1 | competitive fitness: decreased | competitive growth fitness profiling using complete deletion alleles | null Allele: fob1-Δ | S288C | Media: minimal medium Details: Relative fitness score: 0.981 | Breslow DK, et al. (2008) PMID:18622397 | |
| FOB1 | haploinsufficient | heterozygous diploid, competitive growth genome-wide fitness profiling | null Allele: fob1-Δ | S288C | Media: turbidostat growth in FPM medium Details: Relative growth score: -0.0036 | Pir P, et al. (2012) PMID:22244311 | |
| FOB1 | haploinsufficient | heterozygous diploid, competitive growth | null Allele: fob1-Δ | S288C | Treatment: conditions that mimic Phase I of a batch fermentation, equivalent to ~14 hours after inoculation of a batch fermentation | Novo M, et al. (2013) PMID:24040173 | |
| FOB1 | meiotic recombination: increased | homozygous diploid | null Allele: fob1-Δ | Other | Details: increased meiotic rDNA recombination | Casper AM, et al. (2008) PMID:18584028 | |
| FOB1 | mitotic recombination: decreased | homozygous diploid | null Allele: fob1-Δ | Other | Details: decreased mitotic rDNA recombination | Casper AM, et al. (2008) PMID:18584028 | |
| FOB1 | mitotic recombination: decreased | classical genetics | null Allele: fob1-Δ | Other | Details: reduction in Hot1p mediated recombination | Defossez PA, et al. (1999) PMID:10230397 | |
| FOB1 | mitotic recombination: decreased rate | classical genetics | null Allele: fob1-Δ | S288C | Details: decreased rDNA recombination rate | Peng J, et al. (2015) PMID:25822194 |
An interaction is defined as an experimentally observed physical or genetic interaction between two genes. There may be more than one row listed for the same interactor if the interaction between it and the given gene was observed in separate studies. All interactions listed in SGD are curated by BioGRID.
30 entries for 30 genesIncrease the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details about experiment type and any other genes involved in the interaction.
| Interactor | Interactor | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Reference | |
|---|---|---|---|---|---|---|---|---|---|---|
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | FOB1 | ATG2 | atg2-Δ, fob1-Δ | Negative Genetic | high-throughput | Hit-Bait | -0.1446 | 8.818E-62 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | FOB1 | CMI7 | yil002w-a-Δ, fob1-Δ | Negative Genetic | high-throughput | Hit-Bait | -0.1341 | 0.0478 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | FOB1 | DOT1 | fob1-Δ, dot1-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.1442 | 0.02568 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | FOB1 | END3 | end3-supp1, fob1-Δ | Negative Genetic | high-throughput | Hit-Bait | -0.1564 | 0.04615 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | FOB1 | FMS1 | fms1-Δ, fob1-Δ | Negative Genetic | high-throughput | Hit-Bait | -0.1314 | 0.000005759 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | UBP9 | FOB1 | ubp9-Δ, fob1-Δ | Positive Genetic | high-throughput | Bait-Hit | 0.1751 | 8.891E-11 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | BRN1 | FOB1 | brn1-16, fob1-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.2896 | 2.322E-8 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | BRN1 | FOB1 | brn1-9, fob1-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.3902 | 5.867E-19 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | CMD1 | FOB1 | cmd1-1, fob1-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.2897 | 0.0000912 | Costanzo M, et al. (2016) PMID:27708008 | |
Genetic interactions were considered significant if they had a p-value < 0.05 and an SGA score > 0.16 for positive interactions and SGA score < -0.12 for negative interactions. | ALG1 | FOB1 | alg1-1, fob1-Δ | Negative Genetic | high-throughput | Bait-Hit | -0.2665 | 0.001135 | Costanzo M, et al. (2016) PMID:27708008 |
This diagram displays up to the top 30 positive interactions (green), negative interactions (orange), and phenotypes (blue) that are shared between the given allele (black) and other alleles (purple). The shared interactions or phenotypes can be visualized separately using the radio button at the bottom of the graph.
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