Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
6 entries for 5 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|---|
| FIN1 | colony sectoring: increased | classical genetics | overexpression Allele: FIN1-5A S36A, S54A, T68A, S117A, S148A; consensus Cdk1p phosphorylation sites mutated | W303 | Assay: chromosome transmission fidelity (CTF) assay Details: chromosome loss rate per generation increased after a two hour pulse of expression; 7 fold | Woodbury EL and Morgan DO (2007) PMID:17173039 | |
| FIN1 | inviable | classical genetics | overexpression Allele: FIN1-5A S36A, S54A, T68A, S117A, S148A; consensus Cdk1p phosphorylation sites mutated | W303 | Woodbury EL and Morgan DO (2007) PMID:17173039 | ||
| FIN1 | nuclear position: abnormal | classical genetics | overexpression Allele: FIN1-5A S36A, S54A, T68A, S117A, S148A; consensus Cdk1p phosphorylation sites mutated | W303 | Details: the entire nucleus moves to the bud without segregating chromosomes | Akiyoshi B, et al. (2009) PMID:19948764 | |
| FIN1 | protein/peptide distribution: abnormal Reporter: Glc7p-GFP | classical genetics | overexpression Allele: FIN1-5A S36A, S54A, T68A, S117A, S148A; consensus Cdk1p phosphorylation sites mutated | W303 | Treatment: alpha-factor block release Details: Glc7p localizes to the spindle poles and spindle microtubules as opposed to the nucleus and bud neck in 89% of metaphase cells | Akiyoshi B, et al. (2009) PMID:19948764 | |
| FIN1 | spindle morphology: abnormal | classical genetics | overexpression Allele: FIN1-5A S36A, S54A, T68A, S117A, S148A; consensus Cdk1p phosphorylation sites mutated | W303 | Phase: metaphase arrested Details: spindles collapse, with unseparated spindle poles and long astral microtubules | Woodbury EL and Morgan DO (2007) PMID:17173039 | |
| FIN1 | spindle morphology: abnormal | classical genetics | overexpression Allele: FIN1-5A S36A, S54A, T68A, S117A, S148A; consensus Cdk1p phosphorylation sites mutated | W303 | Details: mutant cells have monopolar spindles instead of bipolar spindles | Akiyoshi B, et al. (2009) PMID:19948764 |
This diagram displays up to the top 30 positive interactions (green), negative interactions (orange), and phenotypes (blue) that are shared between the given allele (black) and other alleles (purple). The shared interactions or phenotypes can be visualized separately using the radio button at the bottom of the graph.
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