Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
2 entries for 2 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
---|---|---|---|---|---|---|---|
ATG9 | autophagy: abnormal | classical genetics | reduction of function Allele: atg9-basic R560A, Q576A, R723A; basic rear region of the lateral pore mutated | S288C | Details: compromised symmetrical distribution of phospholipids in autophagosome membranes | Orii M, et al. (2021) PMID:33439214 | |
ATG9 | autophagy: decreased | classical genetics | reduction of function Allele: atg9-basic R560A, Q576A, R723A; basic rear region of the lateral pore mutated | S288C | Treatment: rapamycin, 200 ng/ml Details: reduction in autophagy; partial defect in Ape1 maturation and a severe defect in PGK1-GFP processing in cells treated with rapamycin; decreased size and number of autophagic bodies in vacuolar protease–deficient cells | Matoba K, et al. (2020) PMID:33106658 |
List of references used specifically to curate the information in Overview section.
Addgene Plasmids | DNASU Plasmids | PlasmID | Thermo Scientific | YGRC
dHITS | FitDB | HIPHOP Chemogenomics | HIP HOP Profiles | MetaboGeneCard | PROPHECY | SCMD | ScreenTroll | TheCellVision | Yeast Phenome
BioGRID | CYC2008 | DIP | GeneMANIA | IMP | InterologFinder | ModelArchive | TheCellMap