Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
28 entries for 14 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|---|
| PGS1 | chemical compound accumulation: decreased | classical genetics | null Allele: pgs1-Δ | S288C | cardiolipin | Details: decreased mitochondrial accumulation of cardiolipin | Connerth M, et al. (2012) PMID:23042293 |
| PGS1 | chemical compound accumulation: increased | classical genetics | null Allele: pgs1-Δ | S288C | phosphatidylinositol | Details: increased mitochondrial accumulation of phosphatidylinositol | Connerth M, et al. (2012) PMID:23042293 |
| PGS1 | chemical compound accumulation: increased | classical genetics | null Allele: pgs1-Δ | S288C | CDP-diacylglycerol | Details: increased mitochondrial accumulation of CDP-diacylglycerol | Connerth M, et al. (2012) PMID:23042293 |
| PGS1 | haploinsufficient | heterozygous diploid, systematic mutation set | null Allele: pgs1-Δ | S288C | Ohnuki S and Ohya Y (2018) PMID:29768403 | ||
| PGS1 | haploproficient | heterozygous diploid, competitive growth genome-wide fitness profiling | null Allele: pgs1-Δ | S288C | Media: turbidostat growth in FPM medium Details: Relative growth score: 0.0033 | Pir P, et al. (2012) PMID:22244311 | |
| PGS1 | heat sensitivity: increased | classical genetics | null Allele: pgs1-Δ | Other | Temperature: elevated temperature, 37 °C | Chang SC, et al. (1998) PMID:9545322 | |
| PGS1 | innate thermotolerance: increased | homozygous diploid, systematic mutation set | null Allele: pgs1-Δ | S288C | Phase: exponential phase Treatment: heat shock, 50 °C Details: resistance scale of 1 (least) to 4 (most) resistant: 2 | Jarolim S, et al. (2013) PMID:24142923 | |
| PGS1 | inviable | systematic mutation set | null Allele: pgs1-Δ | S288C | Giaever G, et al. (2002) PMID:12140549 | ||
| PGS1 | mitochondrial morphology: abnormal | classical genetics | null Allele: pgs1-Δ | S288C | Details: mitochondria contained extremely elongated cristae sheets, which remained connected to the inner boundary membrane and frequently formed IM septae or onionlike structures | Connerth M, et al. (2012) PMID:23042293 | |
| PGS1 | petite-negative | classical genetics | null Allele: pgs1-Δ | Other | Details: ethidium bromide sensitive; inability to survive loss of mitochondrial genome on rich media | Chang SC, et al. (1998) PMID:9545322 |
This diagram displays up to the top 30 positive interactions (green), negative interactions (orange), and phenotypes (blue) that are shared between the given allele (black) and other alleles (purple). The shared interactions or phenotypes can be visualized separately using the radio button at the bottom of the graph.
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