Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
17 entries for 16 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|---|
| MCM7 | cell cycle progression in G2 phase: delayed | heterozygous diploid | null Allele: mcm7-Δ | S288C | Details: significant increase in the number of cells in the G2 phase of the cell cycle, indicative of a delay in the G2/M phase transition | Stępień K, et al. (2024) PMID:37907194 | |
| MCM7 | cell size: increased | heterozygous diploid, systematic mutation set analysis of cell size for mutants in the systematic deletion collection | null Allele: mcm7-Δ | S288C | Details: mutant is among the largest 5% of heterozygous diploid deletion strains | Jorgensen P, et al. (2002) PMID:12089449 | |
| MCM7 | chromosome/plasmid maintenance: decreased | heterozygous diploid, systematic mutation set | null Allele: mcm7-Δ | S288C | Assay: diploid bimater (BiM) assay Details: haploinsufficiency results in chromosome instability (CIN); scored >= 2 standard deviations above the mean | Choy JS, et al. (2013) PMID:23825022 | |
| MCM7 | chronological lifespan: abnormal | heterozygous diploid | null Allele: mcm7-Δ | S288C | Details: delayed chronological aging; exhibits delayed senescence during the initial 14 days; incapable of forming colonies beyond 21 days while wt cells remain viable; increased cell size from the onset with declining viability and reduction in ploidy over time | Stępień K, et al. (2024) PMID:37907194 | |
| MCM7 | competitive fitness: decreased | heterozygous diploid, competitive growth genome-wide fitness profiling | null Allele: mcm7-Δ | S288C | Media: YPD Details: Relative fitness score: 0.955 | Deutschbauer AM, et al. (2005) PMID:15716499 | |
| MCM7 | filamentous growth: decreased | systematic mutation set | null Allele: mcm7-Δ | Sigma1278b | Jin R, et al. (2008) PMID:17989363 | ||
| MCM7 | growth in exponential phase: decreased rate | heterozygous diploid | null Allele: mcm7-Δ | S288C | Details: reduction in growth rate with the mean doubling time increasing from 89 min in the wt control to 108 min in the null mutant | Stępień K, et al. (2024) PMID:37907194 | |
| MCM7 | haploinsufficient | heterozygous diploid, competitive growth | null Allele: mcm7-Δ | S288C | Deutschbauer AM, et al. (2005) PMID:15716499 | ||
| MCM7 | haploinsufficient | heterozygous diploid, systematic mutation set | null Allele: mcm7-Δ | S288C | Ohnuki S and Ohya Y (2018) PMID:29768403 | ||
| MCM7 | hyperosmotic stress resistance: increased | heterozygous diploid | null Allele: mcm7-Δ | S288C | 1 M sodium chloride | Details: highly resistant to hyperosmotic stress | Stępień K, et al. (2024) PMID:37907194 |
This diagram displays up to the top 30 positive interactions (green), negative interactions (orange), and phenotypes (blue) that are shared between the given allele (black) and other alleles (purple). The shared interactions or phenotypes can be visualized separately using the radio button at the bottom of the graph.
Addgene Plasmids | DNASU Plasmids | PlasmID | Thermo Scientific | YGRC
dHITS | FitDB | HIPHOP Chemogenomics | HIP HOP Profiles | PhenoM | PROPHECY | SCMD | ScreenTroll | TheCellVision | Yeast Phenome
BioGRID | CYC2008 | DIP | GeneMANIA | IMP | InterologFinder | ModelArchive | TheCellMap