Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
18 entries for 11 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Gene | Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|---|
| RNA1 | chromosome/plasmid maintenance: abnormal | large-scale survey | conditional Allele: rna1-1 | S288C | Assay: gross-chromosomal rearrangement (GCR) assay Temperature: semi-permissive temperature Details: indicative of chromosome instability (CIN); metascore weak (multiple hit) | Stirling PC, et al. (2011) PMID:21552543 | |
| RNA1 | heat sensitivity: increased | classical genetics | conditional Allele: rna1-1 S17F, A194V | Other | Temperature: elevated temperature, 34 °C Details: the presence of both mutations is required for the increase in heat sensitivity; single mutants are not heat sensitive | Traglia HM, et al. (1989) PMID:2674676 | |
| RNA1 | nuclear export: decreased Reporter: scR1 | classical genetics | conditional Allele: rna1-1 | Other | Temperature: elevated temperature, 37 °C Details: weak defect | Grosshans H, et al. (2001) PMID:11352936 | |
| RNA1 | nuclear import: decreased Reporter: GFP-Npl3p | classical genetics | conditional Allele: rna1-1 | Other | Temperature: elevated temperature, 36 °C Details: reporter mislocalized to the cytoplasm | Corbett AH, et al. (1995) PMID:7657689 | |
| RNA1 | nuclear import: decreased Reporter: GFP-Sec65p | classical genetics | conditional Allele: rna1-1 | Other | Temperature: elevated temperature, 37 °C Details: cytoplasmic accumulation observed | Grosshans H, et al. (2001) PMID:11352936 | |
| RNA1 | nuclear import: decreased Reporter: GFP-Srp21p | classical genetics | conditional Allele: rna1-1 | Other | Temperature: elevated temperature, 37 °C Details: cytoplasmic accumulation observed | Grosshans H, et al. (2001) PMID:11352936 | |
| RNA1 | nuclear import: decreased Reporter: GFP-Srp72p | classical genetics | conditional Allele: rna1-1 | Other | Temperature: elevated temperature, 37 °C Details: cytoplasmic accumulation observed | Grosshans H, et al. (2001) PMID:11352936 | |
| RNA1 | nucleolar morphology: abnormal | systematic mutation set | conditional Allele: rna1-1 | S288C | Temperature: elevated temperature, 37 °C Details: increased nucleolar fragmentation; high confidence candidate | Neumüller RA, et al. (2013) PMID:23962978 | |
| RNA1 | protein/peptide distribution: abnormal Reporter: Ace2-YFP | classical genetics | conditional Allele: rna1-1 | Other | Temperature: elevated temperature, 37 °C Details: class III mutant; strong symmetric localization of Ace2p in anaphase-telophase mother and daughter cells, rather than asymmetric localization of Ace2p in daughter cell nuclei of late mitotic cells | Herrero E, et al. (2020) PMID:32878900 | |
| RNA1 | protein/peptide distribution: abnormal Reporter: Ace2-YFP | systematic mutation set | conditional Allele: rna1-1 | Other | Temperature: elevated temperature, 37 °C Details: class III mutant; symmetric localization of Ace2p restricted to late mitotic mother and daughter cells, rather than asymmetric localization of Ace2p in daughter cell nuclei of wt telophase cells | Herrero E, et al. (2020) PMID:32878900 |
An interaction is defined as an experimentally observed physical or genetic interaction between two genes. There may be more than one row listed for the same interactor if the interaction between it and the given gene was observed in separate studies. All interactions listed in SGD are curated by BioGRID.
Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details about experiment type and any other genes involved in the interaction.
| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
|---|
This diagram displays up to the top 30 positive interactions (green), negative interactions (orange), and phenotypes (blue) that are shared between the given allele (black) and other alleles (purple). The shared interactions or phenotypes can be visualized separately using the radio button at the bottom of the graph.
List of references used specifically to curate the information in Overview section.
Addgene Plasmids | DNASU Plasmids | PlasmID | Thermo Scientific | YGRC
dHITS | FitDB | HIPHOP Chemogenomics | HIP HOP Profiles | PhenoM | PROPHECY | SCMD | ScreenTroll | TheCellVision | Yeast Phenome
BioGRID | CYC2008 | DIP | GeneMANIA | IMP | InterologFinder | ModelArchive | TheCellMap