Complex: DCS1 decapping scavenger complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-1179
- Systematic Name
- 2xDCS1
- SGD ID
- SGD:S000217608
- Aliases
- DCS1 homodimer complex ; DcpS complex
- Description
- m7G(5')pppN diphosphatase which degrades the 5-prime mRNA cap when the cap is no longer attached to the mRNA body but rather within short capped mRNA fragments that are generated from 3' to 5' mRNA decay. Releases m7GMP. Mononucleoside diphosphates (m7GDP and m3 2,2,7GDP) are not hydrolyzed by the complex, however mononucleoside triphosphates (m7GTP and m3 2,2,7GTP) are, demonstrating the importance of a triphosphate chain for DCS1 hydrolytic activity. Has a high binding affinity for m7GDP, which inhibits the complex, making this mononucleoside diphosphate a potential regulator of cap-dependent cellular processes.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables RNA 7-methylguanosine cap binding (IDA)
- enables m7G(5')pppN diphosphatase activity (IDA)
- enables mRNA 5'-diphosphatase activity (IDA)
- Biological Process
-
- involved in nuclear-transcribed mRNA catabolic process (IDA)
- Cellular Component
-
- located in perinuclear region of cytoplasm (IDA)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Fuchs AL, et al. (2020) Molecular basis of the selective processing of short mRNA substrates by the DcpS mRNA decapping enzyme. Proc Natl Acad Sci U S A 117(32):19237-19244 PMID: 32723815
- Wypijewska A, et al. (2012) 7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity. Biochemistry 51(40):8003-13 PMID: 22985415
Resources
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